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We patch more than 400 applications

Can I use the same Assignment Profile on more than one application?

Yes, you can use the same Assignment Profile on as many applications as you like. But only one Assignment Profile can be assigned to an application at a time.

I wish to deploy an application in stages, based on days from an application is updated/created or on dynamic dates – for instance every second Tuesday of the month – How can I accomplish this with Assignment Profile?

You can use Deployment Schedules for this purpose, which make use of Assignment Profile to accomplished this goal. Learn more about Deployment Schedules here

I’m trying to assign my new Assignment Profile to an application, but it is greyed out?

You can only assign an Assignment Profile to an application that is already deployed to your Intune.